| Date | Details | Results | Alerts |
|---|---|---|---|
| 08/20/10 07:00 pm | Madison Consolidated (0-6-1) Madison | W49-26 | |
| 08/27/10 07:00 pm | Brownstown Central (11-2) CHARLESTOWN (drf) | L47-8 | |
| 09/03/10 07:00 pm | @Clarksville (1-5-2) CLARKSVILLE | W44-14 | |
| 09/10/10 07:00 pm | @Eastern (Pekin) (5-5) Eastern | W42-30 | |
| 09/17/10 07:00 pm | Providence (4-4-2) Charlestown | L28-16 | |
| 09/24/10 07:00 pm | Corydon Central (8-2) CHARLESTOWN (drf) | L22-13 | |
| 10/01/10 07:00 pm | @Salem (0-8-1) SALEM | W44-2 | |
| 10/08/10 07:00 pm | North Harrison (2-7) CHARLESTOWN (drf) | W41-14 | |
| 10/15/10 07:00 pm | Lawrenceburg (2-2) CHARLESTOWN (drf) | W39-20 | |
| 10/22/10 07:30 pm | Edgewood (3-4) IHSAA Sectional Game | W28-21 | |
| 10/29/10 07:00 pm | Brown County (2-6) IHSAA Sectional Game | W54-20 | |
| 11/05/10 07:30 pm | @Indian Creek (12-2) IHSAA Sectional Final Game at Indiana Creek High School | L48-28 |
